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KMID : 0438420100170010039
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Korean Journal of Bone Metabolism
2010 Volume.17 No. 1 p.39 ~ p.47
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The Relationship between Visfatin and Resistin Gene Polymorphisms with Bone Mineral Density in a Korean Population
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Oh Ki-Won
Yun Eun-Joo
Jang Eun-Hee
Baek Ki-Hyun
Yoon Kun-Ho
Kang Moo-Il
Son Ho-Young
Lee Won-Chul
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Abstract
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Objective: Adipokines have been proposed as link molecules between adiposity and osteoporosis, but the relationship between novel adipokine gene polymorphisms and bone metabolism in human is not clear. The aim of this study was to investigate the relationship between visfatin and resistin gene polymorphisms and bone mineral density (BMD) in a Korean population.
Methods: In 256 Korean (mean age 67.6 years; male frequency 50%), lumbar spine, total femur, femoral neck and trochanter BMD were examined by dual energy X-ray absorptiometry. Genotyping of visfatin -1535 T>C, -1001 T>G, -948 G>T and resistin -420 C>G gene polymorphisms were performed by allelic discrimination using the 5’ nuclease polymerase chain reaction assay.
Results: Allele frequencies of visfatin -1535 T>C were 0.58 for T allele and 0.42 for C allele; of resistin -420 C>G were 0.67 for C allele and 0.33 for G allele. All the frequencies of the genotypes were in compliance with Hardy-Weinberg equilibrium. Mean BMDs of total femur were significantly higher in TT genotype compared with TC and CC genotypes of visfatin -1535 T>C polymorphism, and this significance disappeared after adjustment for age and body mass index (BMI). No significant differences were observed in mean BMDs of lumbar spine, femoral neck and trochanter regarding visfatin -1535 T>C polymorphism. Mean BMDs of total femur, femoral neck and trochanter were significantly higher in CC genotype compared with CG and GG genotypes of resistin -420 C>G polymorphism, and these significances were persistent even after adjustment for age and BMI. Mean BMDs of lumbar spine were significantly higher in CC genotype compared with CG and GG genotypes of resistin -420 C>G polymorphism, and this significance disappeared after adjustment for age and BMI.
Conclusion: Resistin -420 C>G gene polymorphisms were associated with femoral BMDs in a Korean population. Thus, we can guess that resistin gene may influences on the bone mass, but it remains unclear whether the polymorphisms in the resistin gene have a direct functional impact on the bone metabolism.
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KEYWORD
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Resistin, Visfatin, Polymorphism, Bone mineral density
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